Open AccessMarked Healing-Promoting Action of Cimetidine on Acetic Acid-Induced Ulcer in Rats with a Limited Food-Intaking-Time
Author(s) -
Mikio Ito,
Tamio Tsukahara,
Yoshio Suzuki
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.41.260
Subject(s) - cimetidine , acetic acid , limiting , medicine , gastroenterology , pharmacology , chemistry , biochemistry , mechanical engineering , engineering
The effect of cimetidine on ulcer healing was investigated in rats with acetic acid induced ulcer who were permitted to intake food only between 9:30-10:30 a.m. and 6:00-7:00 p.m. When evaluated on the 15th and 21st days after operation, cimetidine (100 mg/kg X 2/day, p.o.) markedly decreased the ulcer index and the defective area of the ulcerated region. Moreover, this agent pronouncedly increased the decreasing index of exposed ulcer floor and the mucosal regeneration index. On the 21st day, the thickness of the ulcer base was decreased by this agent, the involution of granulation being indicated. Thus, marked healing-promoting action of cimetidine on acetic acid-induced ulcer was observed by limiting the food-intaking-time.