Open AccessEffect of Caerulein with Haloperidol on Monoamine Contents in Rat Brain Regions Treated with Methamphetamine
Author(s) -
Masahisa Hashimoto,
Takafumi Hirai,
Katsuji Oguchi,
Hajime Yasuhara
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.41.127
Subject(s) - methamphetamine , haloperidol , monoamine neurotransmitter , dopamine , serotonin , chemistry , endocrinology , medicine , pharmacology , amphetamine , receptor
To elucidate the mechanism of the antagonistic effect of caerulein on amphetamine-induced hyperactivity, monoamine contents in rat brain regions were measured by HPLC. With a combination of caerulein and haloperidol, dopamine contents in methamphetamine treated-rats were significantly decreased in the striatum. Noradrenaline contents were significantly decreased in the haloperidol-methamphetamine group, but caerulein restored it to the normal levels. Serotonin contents did not change in any of the groups tested. These results may indicate that caerulein acts as a neuromodulator in rat brain and causes suppression of hyperactivity induced by methamphetamine.