Effect of Caerulein with Haloperidol on Monoamine Contents in Rat Brain Regions Treated with Methamphetamine | Zendy

Miyuki Hashimoto | Zendy; Takafumi Hirai | Zendy; Katsuji Oguchi | Zendy; Hajime Yasuhara | Zendy

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Effect of Caerulein with Haloperidol on Monoamine Contents in Rat Brain Regions Treated with Methamphetamine

Author(s) -

Miyuki Hashimoto,

Takafumi Hirai,

Katsuji Oguchi,

Hajime Yasuhara

Publication year - 1986

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.41.127

Subject(s) - methamphetamine , haloperidol , monoamine neurotransmitter , dopamine , serotonin , chemistry , endocrinology , medicine , pharmacology , amphetamine , receptor

To elucidate the mechanism of the antagonistic effect of caerulein on amphetamine-induced hyperactivity, monoamine contents in rat brain regions were measured by HPLC. With a combination of caerulein and haloperidol, dopamine contents in methamphetamine treated-rats were significantly decreased in the striatum. Noradrenaline contents were significantly decreased in the haloperidol-methamphetamine group, but caerulein restored it to the normal levels. Serotonin contents did not change in any of the groups tested. These results may indicate that caerulein acts as a neuromodulator in rat brain and causes suppression of hyperactivity induced by methamphetamine.

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