Cardiotonic and Coronary Vasodilatatory Effects of Amrinone in the Canine Heart-Lung Preparation with a Support Dog as Compared with Those of Dobutamine | Zendy

Keisuke Takeda | Zendy; Kazuki Matsui | Zendy; Mikio Nakazawa | Zendy; H Nakahara | Zendy; Hirohisa Imai | Zendy; Shoichi Imai | Zendy

Open Access

Cardiotonic and Coronary Vasodilatatory Effects of Amrinone in the Canine Heart-Lung Preparation with a Support Dog as Compared with Those of Dobutamine

Author(s) -

Keisuke Takeda,

Kazuki Matsui,

Mikio Nakazawa,

H Nakahara,

Hirohisa Imai,

Shoichi Imai

Publication year - 1986

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.40.381

Subject(s) - amrinone , inotrope , dobutamine , chronotropic , coronary vasodilator , cardiology , vasodilation , medicine , hemodynamics , heart rate , blood pressure

Analysis of the relative magnitude of the positive inotropic and chronotropic effects and the coronary vasodilating effects of amrinone conducted in the canine heart-lung preparation with a support dog in comparison with those of dobutamine demonstrated that amrinone was a preferential coronary vasodilator rather than a selective positive inotropic agent. An in vitro experiment in the canine papillary muscle suggested the initiation of the slow response action potential as a mechanism of the positive inotropic effect of amrinone.

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