Open AccessCardiotonic and Coronary Vasodilatatory Effects of Amrinone in the Canine Heart-Lung Preparation with a Support Dog as Compared with Those of Dobutamine
Author(s) -
Kazuki Takeda,
Kazuki Matsui,
Makoto Nakazawa,
Hiroyuki Nakahara,
Hirotatsu Imai,
Shoichi Imai
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.40.381
Subject(s) - amrinone , inotrope , chronotropic , dobutamine , coronary vasodilator , vasodilation , cardiology , medicine , hemodynamics , heart rate , blood pressure
Analysis of the relative magnitude of the positive inotropic and chronotropic effects and the coronary vasodilating effects of amrinone conducted in the canine heart-lung preparation with a support dog in comparison with those of dobutamine demonstrated that amrinone was a preferential coronary vasodilator rather than a selective positive inotropic agent. An in vitro experiment in the canine papillary muscle suggested the initiation of the slow response action potential as a mechanism of the positive inotropic effect of amrinone.