Open AccessCephalothin and Penicillin G Polymers as Elicitors of Rat PCA Mediated by Mouse IgE Antibodies
Author(s) -
Minoru Harada,
Akira Watanabe,
Mitsuo Takeuchi,
Yasuko Niinomi
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.40.178
Subject(s) - penicillin , immunoglobulin e , antibody , chemistry , polymer , immunization , immunology , antibiotics , biochemistry , biology , organic chemistry
PCA-eliciting activities of cephalothin- and penicillin G-polymers were examined in rats sensitized with homologous IgE antibodies of mouse origin. Cephalothin-polymers elicited PCA regardless of the source of antibodies and the methods to raise them, the minimal effective dose being 2 to 20 micrograms/animal. Penicillin G-polymers provoked PCA only when anti-benzylpenicilloyl IgE antibody of C57BL/6J mouse raised early after immunization was used. The minimal effective dose in this case was 5 micrograms/animal, being comparable to that of cephalothin polymers.