Open AccessChanges of Total Acetylcholine Content and the Activity of Related Enzymes in SART (Repeated Cold)-Stressed Rat Brain and Duodenum
Author(s) -
Tomitaro Kita,
Taeko Hata,
Takashi Higashiguchi,
Eiji Itoh,
Atsufumi Kawabata
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.40.174
Subject(s) - acetylcholine , acetylcholinesterase , choline acetyltransferase , aché , basal ganglia , endocrinology , medicine , duodenum , choline , hypothalamus , basal (medicine) , cholinergic , biology , central nervous system , enzyme , biochemistry , insulin
In SART-stressed rats regarded as pathologically diseased model animals with vagotonic-type autonomic imbalance, a decrease of total acetylcholine (T-ACh) content and enhancements of choline acetyltransferase (CAT) and acetylcholinesterase (AChE) activities were recognized in the basal ganglia and hypothalamus. In contrast, in the duodenum, an increase in T-ACh content and a decrease in AChE activity were found, while CAT activity showed no change. These findings suggest that in both brain areas of basal ganglia and hypothalamus in SART-stressed rats, ACh neurons may be activated.