Open AccessEarly Effects of 2-Acetylaminofluorene and N-Hydroxy-2-Acetylaminofluorene on Mitochondrial Outer Membrane Enzyme Activities of Rat Liver
Author(s) -
Takemi Yoshida,
Toshinori Yamamoto,
Yoshiharu Matsuura,
Yukio Kuroiwa
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.475
Subject(s) - 2 acetylaminofluorene , monoamine oxidase , carcinogen , chemistry , enzyme , mitochondrion , metabolite , biology , biochemistry , microsome
During the early stages of the carcinogen 2-acetylaminofluorene (2-AAF) feeding, there were marked decreases of hepatic mitochondrial type B monoamine oxidase (MAO) and kynurenine 3-hydroxylase activities in male rats, but not in female rats. The administration of N-hydroxy-2-AAF (N-OH-2-AAF), a proximate carcinogenic metabolite of 2-AAF, to male rats also resulted in the decrease of both enzyme activities. The findings indicate that type B MAO and kynurenine 3-hydroxylase which reside in the outer mitochondrial membranes are susceptible to 2-AAF during the early stages of its hepatocarcinogenesis.