Open AccessEffects of Bifemelane Hydrochloride (MCI-2016) on Acetylcholine Release from Cortical and Hippocampal Slices of Rats
Author(s) -
Kenichi Saitô,
Sachiko Honda,
Mitsuo Egawa,
Akihiro Tobe
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.410
Subject(s) - acetylcholine , monoaminergic , reserpine , hippocampal formation , chemistry , endocrinology , medicine , hydrochloride , serotonin , biochemistry , receptor
Bifemelane hydrochloride (MCI-2016) increased high K+-evoked acetylcholine (ACh) release from cortical and hippocampal slices of rats. The increasing effect of MCI-2016 was abolished in the absence of Ca ion and by pretreatment of reserpine (2.5 mg/kg, i.p.). These results suggest that monoaminergic neurons may be related to the enhancement of ACh release by MCI-2016. High K+-evoked ACh release from cortical slices was significantly decreased during aging. The decrease in ACh release was ameliorated by pretreatment of MCI-2016 (30 mg/kg, i.p.).