Open AccessEffects of Bifemelane Hydrochloride (MCI-2016) on Acetylcholine and Norepinephrine Release from Cortical Slices of Bilaterally Carotid-Artery-Ligated Mongolian Gerbils
Author(s) -
Kenichi Saitô,
Sachiko Honda,
Mitsuo Egawa,
Akihiro Tobe
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.406
Subject(s) - acetylcholine , carotid arteries , norepinephrine , hydrochloride , medicine , gerbil , anesthesia , cardiology , chemistry , dopamine , ischemia , biochemistry
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) and norepinephrine (NE) release from cortical slices of bilaterally carotid-artery-ligated Mongolian gerbils were examined. ACh and NE release from cortical slices of Mongolian gerbils were increased 1 hr after the ligation of bilateral carotid arteries. Pretreatment of MCI-2016 (25 mg/kg, i.p.) attenuated the increase in the release of both neurotransmitters. These effects may participate in the protective effect of MCI-2016 on cerebral ischemia in Mongolian gerbils.