Open AccessVasodilator Effect of Indapamide in Dog Mesenteric Vasculature
Author(s) -
Mizuo Miyazaki,
Shinya Morishita,
Noboru Toda
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.402
Subject(s) - indapamide , hydralazine , vasodilation , medicine , mesenteric arteries , cardiology , chlorothiazide , superior mesenteric artery , artery , diuretic , blood pressure
Effects of indapamide, trichlormethiazide and hydralazine on isolated, perfused dog mesenteric vasculature and helical strips of the dog mesenteric artery were compared. It appears that indapamide-induced hypotension is associated with a direct relaxant action on arterial and arteriolar smooth muscle, whereas hydralazine acts exclusively on resistance vessels.