Open AccessState-Dependent Effects of β-Endorphin on Core Temperature in Stressed and Non-Stressed Rats
Author(s) -
Masatoshi Tanaka,
Akira Tsuda,
Yoshishige Ida,
Itsuko Ushijima,
Shusaku Tsujimaru,
Nobuyuki Nagasaki
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.395
Subject(s) - (+) naloxone , morphine , hypothermia , core temperature , hyperthermia , beta endorphin , opioid , medicine , endocrinology , receptor , state dependent , chemistry , pharmacology , anesthesia , mathematics , mathematical economics
beta-Endorphin, gamma-endorphin, delta-endorphin and morphine injected i.c.v. caused hyperthermia in non-stressed rats; however, the same dose of beta-endorphin and morphine caused hypothermia in stressed animals. These effects of beta-endorphin were antagonized by naloxone. The results suggest that effects of beta-endorphin are different depending on the animal's state and that these effects are mediated via opioid receptors.