Open AccessAntagonism of Picrotoxin Against the Taming Effect of Carbamazepine on Footshock Induced Fighting Behavior in Mice
Author(s) -
Kenzo Nakao,
Takahiro Higashio,
Takashi Inukai
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.281
Subject(s) - picrotoxin , antagonism , carbamazepine , pharmacology , chemistry , neuroscience , psychology , medicine , epilepsy , antagonist , biochemistry , receptor
Carbamazepine (10 and 20 mg/kg, i.p., P less than 0.01; 40 mg/kg p.o., P less than 0.01), Li2CO3 (200 mg/kg, i.p., P less than 0.01; 200 mg/kg, p.o., P less than 0.05), diazepam (0.5 mg/kg, i.p., P less than 0.01) and haloperidol (0.5 mg/kg, i.p., P less than 0.01) significantly decreased the number of fighting episodes induced by footshock in mice. Picrotoxin (0.3 mg/kg, s.c.) and bicuculline (0.5 mg/kg, s.c.) antagonized the effect of carbamazepine or diazepam completely. Our present results suggest that the taming property of carbamazepine in the footshock model have some relation with the GABAergic mechanism.