Open AccessDifferent Sensitivities of Vasoconstrictor Responses to Serotonin and KCI of Isolated and Perfused Dog Mesenteric Arteries with and without Endothelia
Author(s) -
Shigetoshi Chiba,
Miyoko Tsukada
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.271
Subject(s) - serotonin , mesenteric arteries , cannula , chemistry , potassium , medicine , vasoconstriction , endocrinology , anesthesia , artery , surgery , receptor , organic chemistry
The stainless steel cannula inserting method was used to investigate the effects of serotonin on isolated and perfused dog mesenteric arteries with and without intraluminal saponin treatment. By intraluminal administration, serotonin and potassium chloride caused dose-related vasoconstrictions. After intraluminal treatment with 3 mg of saponin, the potassium chloride-induced vasoconstrictor response was significantly enhanced, whereas the serotonin-induced one was not potentiated but rather reduced slightly.