Open AccessCaerulein Antagonism by Benzodiazepines in the Food Intake in Mice
Author(s) -
Keiichi Kubota,
Kiminobu Sugaya,
Ikuko Matsuda,
Yutaka Matsuoka,
Masahiro Itonaga
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.39.120
Subject(s) - antagonism , chlordiazepoxide , diazepam , flurazepam , pharmacology , cholecystokinin , food intake , benzodiazepine , medicine , receptor
Intracisternal administration of caerulein inhibited the food intake in mice, but the caerulein action was antagonized by benzodiazepines such as chlordiazepoxide, diazepam and flurazepam which were administered intraperitoneally in low doses (0.2 to 2 mg/kg). The antagonism mechanism between caerulein and benzodiazepines remains unclear, but the characteristics of the antagonism were similar to those which had been observed with cholecystokinin and benzodiazepines.