Open AccessAutoradiographic Evidence for Dopaminergic Innervation in Guinea Pig Spinal Cord
Author(s) -
Makoto Kondo,
Hiroshi Fujiwara,
Chikako Tanaka
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.38.442
Subject(s) - neuropil , spinal cord , guinea pig , anatomy , dopaminergic , cell bodies , dopamine , dorsum , cord , french horn , neuroscience , biology , chemistry , central nervous system , endocrinology , medicine , psychology , pedagogy , surgery
In studies of the localization of the dopaminergic nerve terminals in the cervical cord of guinea pig, autoradiographic analysis of the spinal cord loaded with [3H]dopamine [( 3H]DA) was done under conditions that prevented the nonspecific uptake of [3H]DA. There was specific labeling in the gray matter and a high density of [3H]DA was present in the dorsal horn (DH). Moderate labeling was observed in the neuropil in the vicinity of the central canal. There were grain concentrations in close approximation to the cell bodies of numerous neurons in the DH and to the cell bodies of a few of the motoneurons in the ventral horn (VH). These dopaminergic terminals are possibly linked to sensory transmission and somatic motor function.