Open AccessAn Analysis of Blood Pressure Effects of Nipradilol and Prizidilol in Normotensive and Spontaneously Hypertensive Rats
Author(s) -
Takushi X. Watanabe,
Hirofumi Sokabe,
Koichiro Kawashima
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.38.273
Subject(s) - cannula , blood pressure , medicine , vasodilation , endocrinology , spontaneously hypertensive rat , plasma renin activity , terbutaline , adrenergic , chemistry , renin–angiotensin system , receptor , surgery , asthma
Nipradilol and prizidilol are beta-adrenoceptor blocking drugs with vasodilator action. These drugs lowered blood pressure (BP) in spontaneously hypertensive (SHR) rats acutely (24 hr) and subacutely (3 weeks) at doses of 10 and 20 mg/kg per day, p.o., respectively. Nipradilol decreased plasma renin concentration in acute and subacute studies, whereas it was unchanged with prizidilol treatment. Paradoxical effects of these drugs on BP were analyzed further: BP determined indirectly at the tail was slightly higher in SHR rats than the control, whereas BP determined directly through an aortic cannula without anesthesia, restraint, or prewarming was lower. We found that the discrepancy between BP values determined directly and indirectly was due to the increase in BP by prewarming stress during the determination by the tail cuff method.