Effects of an Angiotensin I-Converting Enzyme Inhibitor (SA-446) on Renal Function in Dogs | Zendy

Toyokazu Takada | Zendy; Kenjiro Yamamoto | Zendy; Shoji Fujioka | Zendy; Toshiaki Tamaki | Zendy; Kiyoshi Fukui | Zendy; Youichi Abe | Zendy

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Effects of an Angiotensin I-Converting Enzyme Inhibitor (SA-446) on Renal Function in Dogs

Author(s) -

Toyokazu Takada,

Kenjiro Yamamoto,

Shoji Fujioka,

Toshiaki Tamaki,

Kiyoshi Fukui,

Youichi Abe

Publication year - 1985

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.38.227

Subject(s) - probenecid , renal function , chemistry , blood pressure , renal blood flow , endocrinology , renin–angiotensin system , plasma renin activity , medicine , angiotensin converting enzyme , pharmacology , kidney

The effects of an orally active inhibitor of angiotensin-converting enzyme (SA-446) on systemic arterial pressure, renal function and renin release were examined in anesthetized dogs. Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. The smaller dose of SA-446 (0.02 mg/min) did not affect the blood pressure, but it increased the urine flow. However, the same dose of SA-446 in combination with probenecid caused a significant fall in blood pressure. The potentiation of SA-446 with probenecid may be explained by the elevation in plasma SA-446 concentration via the inhibition of its tubular secretion by probenecid.

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