Open AccessEffects of an Angiotensin I-Converting Enzyme Inhibitor (SA-446) on Renal Function in Dogs
Author(s) -
Toyokazu Takada,
Kenjiro Yamamoto,
Shoji Fujioka,
Toshiaki Takahashi,
Kiyoshi Fukui,
Youichi Abe
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.38.227
Subject(s) - probenecid , renal function , chemistry , blood pressure , renal blood flow , endocrinology , renin–angiotensin system , plasma renin activity , medicine , angiotensin converting enzyme , pharmacology , kidney
The effects of an orally active inhibitor of angiotensin-converting enzyme (SA-446) on systemic arterial pressure, renal function and renin release were examined in anesthetized dogs. Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. The smaller dose of SA-446 (0.02 mg/min) did not affect the blood pressure, but it increased the urine flow. However, the same dose of SA-446 in combination with probenecid caused a significant fall in blood pressure. The potentiation of SA-446 with probenecid may be explained by the elevation in plasma SA-446 concentration via the inhibition of its tubular secretion by probenecid.