Open AccessGastric Antral Ulcers Induced by a Combination of Acid, Indomethacin and Ischemia in Rats
Author(s) -
Fumiaki Hirose,
Takuji Mizui,
Noriko Shimono,
Masami Doteuchi
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.38.223
Subject(s) - medicine , ischemia , antrum , etiology , ligation , gastroenterology , gastric antrum , stomach , muscularis mucosae , pathology
Gastric antral lesions were produced with hemorrhages by vascular ligation-induced ischemia in the prepyloric regions in rats. Additional treatments with intraluminal acid application and indomethacin markedly aggravated the lesions. Histological examination showed that the incidence of ulcers which penetrated the muscularis mucosae was nearly 100% upon treatment with a combination of acid, indomethacin and ischemia. This model provides a useful tool for studying gastric ulcer etiology.