Modification of Antinociceptive Action of Morphine by Dopamine Agonist and Antagonist in Mice | Zendy

Katsuo Kamata | Zendy; Kunihiko Ogawa | Zendy; Tsutomu Kameyama | Zendy

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Modification of Antinociceptive Action of Morphine by Dopamine Agonist and Antagonist in Mice

Author(s) -

Katsuo Kamata,

Kunihiko Ogawa,

Tsutomu Kameyama

Publication year - 1985

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.38.113

Subject(s) - apomorphine , haloperidol , morphine , pharmacology , nociception , ed50 , agonist , dopamine receptor , dopaminergic , chemistry , antagonist , dopamine , medicine , endocrinology , receptor

A marked potentiation of the antinociceptive action of morphine was produced by haloperidol, but apomorphine had no effect on the antinociceptive action of morphine in acute experiments. Following chronic treatment with haloperidol, the antinociceptive action of morphine was significantly suppressed by apomorphine, and apomorphine shifted the dose-response curve of morphine to the right and increased the ED50 value of morphine by 2.3-fold. These results suggest that the suppressive action of apomorphine on the antinociceptive effect of morphine in chronic haloperidol-treated mice may be due to an increased sensitivity of post-synaptic dopaminergic receptors to apomorphine.

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