Open AccessCardiovascular Effects of an ionophorous Antibiotic, Lonomycin A, in Anesthetized Dogs
Author(s) -
Katsuharu Tsuchida,
Katsuyoshi Kaneko,
Hironaka Aihara,
Shigetoshi Chiba
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.38.109
Subject(s) - ionomycin , nifedipine , vasodilation , ouabain , coronary vasodilator , pindolol , medicine , cardiology , stimulation , anesthesia , chemistry , pharmacology , calcium , propranolol , sodium , organic chemistry
An intracoronary administration of ionomycin A, a K-selective ionophore, produced coronary vasodilation in the presence of pindolol in anesthetized dogs. Coronary vasodilation induced by ionomycin A, KCI and nifedipine was inhibited by pretreatment with an intracoronary injection of ouabain. This result suggests that lonomycin A-induced coronary vasodilation may be partly due to a stimulation of Na+, K+-ATPase as well as KCI and/or a decrease in Ca2+ influx as well as nifedipine.