Open AccessA Possible Role of Gonad and Renal Prostaglandin E2 on the Development of Hypertension in Spontaneously Hypertensive Rats*
Author(s) -
Tadahiro Matsudaira,
Hiroshi Kuroda,
Tetsuo Satoh
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.37.51
Subject(s) - endocrinology , orchiectomy , medicine , blood pressure , prostaglandin e2 , urinary system , prostaglandin , kidney
A possible role of prostaglandin E2 (PGE2) in the regulation of blood pressure in spontaneously hypertensive rats (SHR) was investigated. The inhibition of PG synthesis by chronic indomethacin treatment accelerated the elevation of blood pressure with the tendency to decrease renal PGE2. We, therefore, confirmed that PGE2 in SHR may play a role in the antihypertensive mechanism. In this connection, the participation of renal PGE2 in the retardation of the development of hypertension in male SHR induced by orchiectomy was examined. Urinary PGE2 which reflects the renal PGE2 level tended to keep a higher level in the castrated group. Urinary electrolytes excretion also inclined to augment in the castrated group throughout the experiment. These results indicate that renal PGE2 may participate in the gonads-mediated blood pressure regulation system, although the mechanism of the retardation of spontaneous hypertension induced by orchiectomy remains obscure.