Changes in Density of Muscarinic Cholinergic Receptor by Adrenergic Denervation with Guanethidine | Zendy

Hiroshi Higuchi | Zendy; Miho Murata | Zendy; Shuji Uchida | Zendy; Hiroshi Yoshida | Zendy

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Changes in Density of Muscarinic Cholinergic Receptor by Adrenergic Denervation with Guanethidine

Author(s) -

Hiroshi Higuchi,

Miho Murata,

Shuji Uchida,

Hiroshi Yoshida

Publication year - 1985

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.37.207

Subject(s) - guanethidine , vas deferens , endocrinology , muscarinic acetylcholine receptor , medicine , quinuclidinyl benzilate , adrenergic , denervation , chemistry , adrenergic receptor , cholinergic , receptor , biology , stimulation

The effects of chronic adrenergic denervation with guanethidine on muscarinic cholinergic receptors (mAChR) were investigated by binding of L-3H-quinuclidinyl benzilate (3H-QNB). Guanethidine treatment decreased the amount of mAChR from 102 to 87 fmoles/mg protein in the heart and from 444 to 388 fmoles/mg protein in the small intestine, but increased it from 223 to 282 fmoles/mg protein in the vas deferens, without changes in its characteristics. These findings suggested that adrenergic innervation has different influences on the mAChR population in different tissues.

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