Open AccessChanges in Density of Muscarinic Cholinergic Receptor by Adrenergic Denervation with Guanethidine
Author(s) -
Hiroshi Handa,
Miho Murata,
Shuji Uchida,
Hiroshi Yoshida
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.37.207
Subject(s) - guanethidine , vas deferens , endocrinology , quinuclidinyl benzilate , muscarinic acetylcholine receptor , medicine , denervation , adrenergic , chemistry , adrenergic receptor , population , receptor , biology , stimulation , environmental health
The effects of chronic adrenergic denervation with guanethidine on muscarinic cholinergic receptors (mAChR) were investigated by binding of L-3H-quinuclidinyl benzilate (3H-QNB). Guanethidine treatment decreased the amount of mAChR from 102 to 87 fmoles/mg protein in the heart and from 444 to 388 fmoles/mg protein in the small intestine, but increased it from 223 to 282 fmoles/mg protein in the vas deferens, without changes in its characteristics. These findings suggested that adrenergic innervation has different influences on the mAChR population in different tissues.