Effect of 2,4,6-Trimtrophenol on Catecholamine Secretion from Perfused Bovine Adrenal Glands | Zendy

Kyozo Yamanaka | Zendy; Shizuo Yamada | Zendy; Eiichi Hayashi | Zendy

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Effect of 2,4,6-Trimtrophenol on Catecholamine Secretion from Perfused Bovine Adrenal Glands

Author(s) -

Kyozo Yamanaka,

Shizuo Yamada,

Eiichi Hayashi

Publication year - 1985

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.37.120

Subject(s) - adrenal medulla , secretion , catecholamine , granule (geology) , medicine , endocrinology , extracellular , chromaffin cell , chemistry , membrane , calcium , adrenal gland , biology , biochemistry , paleontology

2,4,6-Trinitrophenol (PA) evoked a prolonged catecholamine (CA) secretion from perfused bovine adrenal glands. The PA-evoked CA secretion was concentration-dependent, required the presence of extracellular calcium and resulted from a direct action of PA on the chromaffin cells. Furthermore, PA reduced Mg2+-ATPase activities in the plasma membrane-rich microsome and granule-rich fraction from the adrenal medulla. These results indicate that PA evokes CA secretion through the actions on both the chromaffin cell membranes and granule membranes.

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