Open AccessEffect of 2,4,6-Trimtrophenol on Catecholamine Secretion from Perfused Bovine Adrenal Glands
Author(s) -
Kyozo Yamanaka,
Shizuo Yamada,
Eiichi Hayashi
Publication year - 1985
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.37.120
Subject(s) - adrenal medulla , secretion , catecholamine , granule (geology) , medicine , endocrinology , extracellular , chromaffin cell , chemistry , membrane , calcium , adrenal gland , biology , biochemistry , paleontology
2,4,6-Trinitrophenol (PA) evoked a prolonged catecholamine (CA) secretion from perfused bovine adrenal glands. The PA-evoked CA secretion was concentration-dependent, required the presence of extracellular calcium and resulted from a direct action of PA on the chromaffin cells. Furthermore, PA reduced Mg2+-ATPase activities in the plasma membrane-rich microsome and granule-rich fraction from the adrenal medulla. These results indicate that PA evokes CA secretion through the actions on both the chromaffin cell membranes and granule membranes.