Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. | Zendy

Michio Terai | Zendy; Shinji Usuda | Zendy; Izumi KUROIWA | Zendy; Osamu Noshiro | Zendy; Hiroo Maeno | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors.

Author(s) -

Michio Terai,

Shinji Usuda,

Izumi KUROIWA,

Osamu Noshiro,

Hiroo Maeno

Publication year - 1983

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.33.749

Subject(s) - spiperone , dopaminergic , chemistry , dopamine receptor , endocrinology , sulpiride , 5 ht2 receptor , medicine , pharmacology , dopamine receptor d2 , receptor , chlorpromazine , dopamine , serotonin , 5 ht receptor

Effects of YM-09151-2 and five other neuroleptics (haloperidol, spiperone, chlorpromazine, sulpiride and clozapine) on the binding of [3H]-ligands to nine different receptors (alpha 1-adrenergic, alpha 2-adrenergic, beta-adrenergic, muscarinic, D2-dopaminergic, H1-histaminergic, 5HT1-serotonergic, 5HT2-serotonergic and opiate receptors) and on dopamine-sensitive adenylate cyclase were determined using brain membranes in the rat, guinea-pig and dog. The affinity of YM-09151-2 for D2-receptors with a Ki value of 0.1 nM was more than 1000-times higher than that for the other receptors and dopamine-sensitive adenylate cyclase, and it was the greatest among the neuroleptics tested.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research