Open AccessBiochemical aspects of experimental barbital dependence II: Effect on glycometabolism.
Author(s) -
Saiζo Yanaura,
Katsuhiko Kakuno,
Kenzo Nakao,
Eijiro Tagashira
Publication year - 1983
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.33.395
Subject(s) - barbital , chemistry , metabolite , dosing , cerebral cortex , carbohydrate metabolism , medicine , endocrinology , pharmacology , biochemistry , biology , chromatography , organic chemistry
A single injection of barbital increased glycogen, while it decreased glucose and glucose-6-phosphate levels in the rat brain. In long barbital dosing (36 days), however, the metabolite level of carbohydrate was almost recovered to the non-treated level. At the later stage of withdrawal (24-48 hr), all metabolites examined except lactate decreased. Only lactate increased remarkably. The effect of barbital dosing and withdrawal was almost same in the three portions, i.e., the cerebral cortex, brain stem, and cerebellum. Barbital depresses the central glycometabolism, and at the dependent stage (long term barbital dosing, 36 days or more), metabolism was almost same as the control. At the later period of withdrawal, it appeared that lactate was increased because of the hypoxic condition caused by stroke. In conclusion, carbohydrate metabolism can probably serve as a sensitive measure for the development of barbital dependence and the onset of withdrawal.