Open AccessEffect of zotepine on head-twitch induced by L-5-Hydroxytryptophan,mescaline and 2,5-Dimethoxy-4-methylamphetamine in mice and rats.
Author(s) -
Tsuneyuki Yamamoto,
Naoe Tazoe,
Showa Ueki,
Kyoichi Shimomura,
Hisashi Satoh,
Jo Mori
Publication year - 1983
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.33.319
Subject(s) - mescaline , cyproheptadine , haloperidol , pharmacology , hallucinogen , chemistry , serotonin , medicine , receptor , dopamine , biochemistry
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three drugs. The results indicate that zotepine has a potent anti-hallucinogenic effect.