Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats. | Zendy

Emiko Fujii | Zendy; Fujiko Tsukahara | Zendy; Teruko Nomoto | Zendy

Open Access

Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats.

Author(s) -

Emiko Fujii,

Fujiko Tsukahara,

Teruko Nomoto

Publication year - 1982

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.32.903

Subject(s) - medicine , streptozotocin , endocrinology , nicotinamide , hemoglobin , insulin , diabetes mellitus , chemistry , biochemistry , enzyme

The present study deals with the effects of nicotinamide and insulin on glycosylated hemoglobin (HbA1) and blood glucose in thyroidectomized streptozotocin (STZ)-diabetic male rats. Nicotinamide (500 mg/kg body wt., i.p.) significantly decreased the levels of HbA1 and blood glucose in both STZ-treated (65 mg/kg body wt., i.v.) intact and STZ-treated thyroidectomized animals. Administration of NPH-insulin recovered hyperglycemia, and the increased HbA1 in thyroidectomized STZ-diabetic rats to control levels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research