A comparison of antihypertensive effects of Atenolol and Propranolol in the spontaneously hypertensive, DOCA/saline hypertenisve and renal hypertensive rats. | Zendy

Keisuke Takeda | Zendy; Yoshito Nakagawa | Zendy; Wan Pao Chin | Zendy; Shoichi Imai | Zendy

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A comparison of antihypertensive effects of Atenolol and Propranolol in the spontaneously hypertensive, DOCA/saline hypertenisve and renal hypertensive rats.

Author(s) -

Keisuke Takeda,

Yoshito Nakagawa,

Wan Pao Chin,

Shoichi Imai

Publication year - 1982

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.32.283

Subject(s) - atenolol , propranolol , medicine , saline , spontaneously hypertensive rat , endocrinology , heart rate , blood pressure

Antihypertensive effects of a long-term oral regimen of atenolol were studied in SHR, DOCA/saline hypertensive and renal hypertensive rats (one kidney, one clip) in comparison with the effects of propranolol. Both the beta-blockers prevented the development of hypertension in SHR but did not affect that in DOCA/saline and renal hypertensive rats. Both of the beta-blockers produced no acute hypotensive effects on the established DOCA/saline and renal hypertension of the rat, although they produced a decrease in the heart rate.

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