Open AccessA comparison of antihypertensive effects of Atenolol and Propranolol in the spontaneously hypertensive, DOCA/saline hypertenisve and renal hypertensive rats.
Author(s) -
Kazuki Takeda,
Yoshito Nakagawa,
Wan Pao Chin,
Shoichi Imai
Publication year - 1982
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.32.283
Subject(s) - atenolol , propranolol , medicine , saline , spontaneously hypertensive rat , endocrinology , heart rate , blood pressure
Antihypertensive effects of a long-term oral regimen of atenolol were studied in SHR, DOCA/saline hypertensive and renal hypertensive rats (one kidney, one clip) in comparison with the effects of propranolol. Both the beta-blockers prevented the development of hypertension in SHR but did not affect that in DOCA/saline and renal hypertensive rats. Both of the beta-blockers produced no acute hypotensive effects on the established DOCA/saline and renal hypertension of the rat, although they produced a decrease in the heart rate.