Partial agonistic action of morphine in the rat vas deferens. | Zendy

Kunio Ishii | Zendy; Satoshi Yamamoto | Zendy; Takamura Muraki | Zendy; Ryuichi Kato | Zendy

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Partial agonistic action of morphine in the rat vas deferens.

Author(s) -

Kunio Ishii,

Satoshi Yamamoto,

Takamura Muraki,

Ryuichi Kato

Publication year - 1981

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.31.905

Subject(s) - vas deferens , morphine , contraction (grammar) , agonist , potency , (+) naloxone , partial agonist , endocrinology , medicine , antagonist , chemistry , receptor , in vitro , biochemistry

Effects of morphine on the force of contraction of rat vas deferens were investigated. Morphine and beta-endorphin decreased the electrically evoked twitch tension, in a dose dependent manner. The inhibitory effect of morphine, however, was much weaker than that of beta-endorphin. These effects of both morphine and beta-endorphin were completely antagonized by naloxone. In the presence of 30 microM morphine, the dose-response curve of beta-endorphin shifted to the right by about 10-fold. Moreover, morphine partly reversed the contraction depressed by 0.3 microM beta-endorphin, in a dose dependent manner. These findings suggest that morphine acts as a partial agonist on the rat vas deferens. Marked tolerance to beta-endorphin and change in the antagonist potency of morphine were not observed in the vas deferens isolated from morphine-dependent rats.

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