Open AccessActions of desoxynupharidine hydrochloride in the central nervous system of cats (II).
Author(s) -
Yukiko Suzuki,
Kyoji Taguchi,
Yukihiko Hagiwara,
Kazuyo Kajiyama,
Takato Ikeda
Publication year - 1981
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.31.653
Subject(s) - stimulation , reticular formation , cats , central nervous system , neuroscience , midbrain reticular formation , hypothalamus , inhibitory postsynaptic potential , brainstem , chemistry , reticular activating system , endocrinology , somatosensory system , medicine , biology
Effects of desoxynupharidine hydrochloride (DN) on the central nervous system of cats were studied using electric physiological techniques. With regard to the EEG arousal responses, DN (1-3 mg/kg, i.v.) inhibited the responses induced by midbrain reticular formation and posterior hypothalamus (P-Hypo) stimulation. The threshold voltage of stimulation was elevated. DN decreases the amplitude of the augmenting response and the recruiting response induced by the stimulation of specific and non-specific pathways in the thalamus. As to the evoked potentials in the somatosensory area I, DN decreased the amplitude of the fast and late components. This compound slightly inhibited the monosynaptic and polysynaptic reflexes, in the spinal cats. With regard to autonomic responses on stimulation of the P-Hypo, DN decreased contractions in the nictitating membrane, the hypertensive action and the galvanic skin response. Our findings indicate that the inhibitory effects of DN on the central nervous system may be related to the brainstem reticular formation and the hypothalamus activating system, the non-specific pathway, the specific pathway and the limbic system etc., and may involve the central anti-adrenergic actions.