Aspirin Inhibition of Hypercalcemic Effect of 1 α-Hydroxyvitamin D3 in Rats. | Zendy

Koichi Ueno | Zendy; Hiroyuki Kawashima | Zendy; Norio Ohnuma | Zendy; Seiji Kurozumi | Zendy; Yoshinobu Hashimoto | Zendy; Hajime Orimo | Zendy

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Aspirin Inhibition of Hypercalcemic Effect of 1 α-Hydroxyvitamin D3 in Rats.

Author(s) -

Koichi Ueno,

Hiroyuki Kawashima,

Norio Ohnuma,

Seiji Kurozumi,

Yoshinobu Hashimoto,

Hajime Orimo

Publication year - 1980

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.30.675

Subject(s) - endocrinology , aspirin , medicine , bone resorption , chemistry , resorption , calcium , vitamin , vitamin d and neurology , diphosphonates , parathyroid hormone

Interaction of calcium regulating hormone, active form of vitamin D3, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D3 (1 alpha-OH-D3) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectomized and thyroparathyroidectomized nephrectomized rats. The effect of 1 alpha-OH-D3 was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1 alpha OH-D3 induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1 alpha-OH-D3, although partial inhibition of bone resorption in vitro has been reported.

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