Open AccessAspirin Inhibition of Hypercalcemic Effect of 1 α-Hydroxyvitamin D3 in Rats.
Author(s) -
Koichi Ueno,
Hiroyuki Kawashima,
Norio Ohnuma,
Seizi Kurozumi,
Yoshinobu Hashimoto,
Hajime Orimo
Publication year - 1980
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.30.675
Subject(s) - endocrinology , aspirin , medicine , bone resorption , chemistry , resorption , calcium , vitamin , vitamin d and neurology , diphosphonates , parathyroid hormone
Interaction of calcium regulating hormone, active form of vitamin D3, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D3 (1 alpha-OH-D3) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectomized and thyroparathyroidectomized nephrectomized rats. The effect of 1 alpha-OH-D3 was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1 alpha OH-D3 induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1 alpha-OH-D3, although partial inhibition of bone resorption in vitro has been reported.