Open AccessAnti-anaphylactic activities of a new benzopyranopyridine derivative Y-12,141 in rats and guinea pigs.
Author(s) -
Kazuhiro Goto,
Michio Terasawa,
Yukinobu Kadobe,
Yutaka Maruyama
Publication year - 1980
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.30.537
Subject(s) - bronchoconstriction , disodium cromoglycate , guinea pig , immunoglobulin e , pharmacology , egg albumin , medicine , anaphylaxis , anaphylactic reactions , inhibitory postsynaptic potential , asthma , immunology , antibody , chemistry , allergy , endocrinology , chromatography
The active anaphylactic bronchoconstriction of rats mediated by IgE-like antibody against DNP-Ascaris was inhibited by intravenous and intratracheal treatment with Y-12,141 in a dose-dependent manner. In both routes, the inhibitory effect of Y-12,141 on this response was more potent than that of disodium cromoglycate (DSCG). The oral administration of Y-12,141 also produced a similar inhibition of the response. The passive anaphylactic bronchoconstriction of guinea pigs mediated by IgG-like antibody against egg albumin was also prevented dose-dependently by treatment with Y-12,141 given intravenously, but not with DSCG. The present results suggest that Y-12,141 may be effective for the treatment of allergic bronchial asthma.