Open AccessModification of drug-induced catatonia and tremors by quipazine in rats and mice.
Author(s) -
Kulkarni Sk,
Ardeshir Arzi,
Pushkar N. Kaul
Publication year - 1980
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.30.129
Subject(s) - quipazine , pharmacology , serotonergic , serotonin agonist , medicine , histaminergic , agonist , drug , amantadine , serotonin , diphenhydramine , cyproheptadine , cholinergic , receptor , histamine
Administration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations of this drug with other antiparkinsonian agents such as scopolamine, diphenhydramine and amantadine were also studied in the manifestation of Parkinson-like symptoms in the animal models. The results indicate that quipazine, a central serotonergic agent, counteracted some of the drug-induced symptoms of pseudoparkinsonism in laboratory animals. Cholinergic, dopaminergic and histaminergic receptors play an important role in the manifestations of these symptoms.