INHIBITORY ACTION OF 6-ETHYL-3-(lH-TETRAZOL-5-YL)CHROMONE (AA-344) ON IgE-, IgGa- OR CHEMICAL AGENT-INDUCED HISTAMINE RELEASE FROM ISOLATED RAT MAST CELLS | Zendy

Taketoshi Saijo | Zendy; Yasuko Ashida | Zendy; Hisashi Kuriki | Zendy; Mono KANNO | Zendy; Yoshitaka Maki | Zendy

Open Access

INHIBITORY ACTION OF 6-ETHYL-3-(lH-TETRAZOL-5-YL)CHROMONE (AA-344) ON IgE-, IgGa- OR CHEMICAL AGENT-INDUCED HISTAMINE RELEASE FROM ISOLATED RAT MAST CELLS

Author(s) -

Taketoshi Saijo,

Yasuko Ashida,

Hisashi Kuriki,

Mono KANNO,

Yoshitaka Maki

Publication year - 1979

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.29.531

Subject(s) - histamine , chromone , inhibitory postsynaptic potential , chemistry , pharmacology , immunoglobulin e , immunology , endocrinology , biology , stereochemistry , antibody

The antiallergic action of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) was studied on isolated rat peritoneal mast cells. AA-344 clearly inhibited the IgE-mediated release of histamine caused by various concentrations of antigen and the 50% inhibitory concentration was 0.1 microM. On the IgGa-mediated release of histamine, a peak inhibition of AA-344 was observed at 10 microM. The histamine release induced by chemical agents such as concanavalin A, dextran and compound 48/80 was depressed by AA-344 at the range of 0.1--1 mM. The results obtained in this study indicate that the antiallergic action of AA-344 is due to selective inhibition on the immunological release of the chemical mediator from mast cells.

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