Open AccessRESPONSIVENESS AND HIGH-ENERGY PHOSPHATEMETABOLISM OF ISOLATED DOG CORONARY ARTERIES
Author(s) -
Matao Sakanashi,
Makie Higuchi,
Fumio Takenaka
Publication year - 1979
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.29.525
Subject(s) - creatine , medicine , coronary arteries , potassium , phosphate , norepinephrine , chemistry , endocrinology , energy metabolism , high energy phosphate , cardiology , metabolism , artery , phosphocreatine , biochemistry , dopamine , organic chemistry
The relationship between responsiveness and high-energy phosphate metabolism was observed in isolated dog coronary arterial strips before and after equilibration, under aerobic conditions. The strips responded slowly to potassium, norepinephrine, isoproterenol and 5-hydroxytryptamine before being equilibrated but did respond quickly to these drugs after being equilibrated for 1 hour under aerobic conditions. The contents of ATP, creatine phosphate (CP) and lactate were not significantly altered before and after equilibration for 1 hr. It is proposed that, before being equilibrated under aerobic conditions, coronary arteries may be unable to utilize ATP and CP due to injury of contractile or relaxant mechanisms resulting in a weak vascular responsiveness.