RESPONSIVENESS AND HIGH-ENERGY PHOSPHATEMETABOLISM OF ISOLATED DOG CORONARY ARTERIES | Zendy

Matao Sakanashi | Zendy; Makie Higuchi | Zendy; Fumio Takenaka | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

RESPONSIVENESS AND HIGH-ENERGY PHOSPHATEMETABOLISM OF ISOLATED DOG CORONARY ARTERIES

Author(s) -

Matao Sakanashi,

Makie Higuchi,

Fumio Takenaka

Publication year - 1979

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.29.525

Subject(s) - creatine , medicine , coronary arteries , potassium , phosphate , norepinephrine , chemistry , endocrinology , energy metabolism , high energy phosphate , cardiology , metabolism , artery , phosphocreatine , biochemistry , dopamine , organic chemistry

The relationship between responsiveness and high-energy phosphate metabolism was observed in isolated dog coronary arterial strips before and after equilibration, under aerobic conditions. The strips responded slowly to potassium, norepinephrine, isoproterenol and 5-hydroxytryptamine before being equilibrated but did respond quickly to these drugs after being equilibrated for 1 hour under aerobic conditions. The contents of ATP, creatine phosphate (CP) and lactate were not significantly altered before and after equilibration for 1 hr. It is proposed that, before being equilibrated under aerobic conditions, coronary arteries may be unable to utilize ATP and CP due to injury of contractile or relaxant mechanisms resulting in a weak vascular responsiveness.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research