Open AccessEFFECTS OF SURUGATOXIN ON ADRENERGIC ALLYINNERVATED TISSUES
Author(s) -
Shizuo Yamada,
Eiichi Hayashi
Publication year - 1979
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.29.295
Subject(s) - vas deferens , endocrinology , tyramine , medicine , nicotine , histamine , adrenergic , stimulation , acetylcholine , nicotinic agonist , chemistry , ileum , norepinephrine , hypogastric nerve , guinea pig , receptor , biology , dopamine
Effects of surugatoxin (SGTX), a new ganglionic blocking agent on adrenergically innervated tissues: guinea pig isolated atria and vas deferens were investigated. SGTX (1, 10 muM) markedly reduced the cardiostimulatory response of the atria to nicotine and also partially the response to 1,1-dimethyl-4-phenylpiperazinium (DMPP) and 5-hydroxytryptamine, without affecting responses to noradrenaline, tyramine and histamine. The contractile response of the vas deferens to nicotine, DMPP and hypogastric nerve stimulation was markedly reduced by SGTX (1, 10 muM), whereas that to noradrenaline, acetylcholine and transmural stimulation was not affected. These results indicate that SGTX has an antagonistic action on nicotinic receptors in these tissues as well as in sympathetic ganglia and in guinea pig ileum.