Open AccessEFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE
Author(s) -
A. Kizu,
Taizo Nakamura,
Syuji Kato,
Katsunori Sawada,
Hamao Ijichi,
Kinya Kuriyama
Publication year - 1977
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.27.817
Subject(s) - haloperidol , chlorpromazine , diazepam , perphenazine , avoidance response , chemistry , physostigmine , chlordiazepoxide , pharmacology , endocrinology , cyproheptadine , pimozide , clonidine , medicine , serotonin , dopamine , acetylcholine , receptor
The major part of orally administered beta-pyridylcarbinol was converted to nicotinic acid in the gastrointestinal tract, whereas that administered intraperitoneally was partially converted to nicotinic acid in the liver. The conversion of this compound to nicotinic acid in both the gastrointestinal tract and liver involved enzymatic processes. The converted nicotinic acid from beta-pyridylcarbinol may play a dominant role in the biological actions of beta-pyridylcarbinol and possibly involves in the synthesis of NAD via Preiss-Handler's pathway.