Open AccessSTUDIES ON CYCLIC NUCLEOTIDES IN THE ADRENAL GLAND V. ADENYLATE CYCLASE IN THE ADRENAL MEDULLA
Author(s) -
Sumio Shima,
Yoshiko Kawashima,
Masanao Hirai,
Hiroshi Kouyama
Publication year - 1976
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.26.711
Subject(s) - adrenal medulla , catecholamine , cyclase , endocrinology , medicine , adenylate kinase , secretion , medulla , chemistry , acetylcholine , adrenal gland , biology , stimulation , receptor
Effects of various chemical agents eliciting the catecholamine-release on the adenylate cyclase-cyclic AMP generating system have been studied in the secretory process of the bovine adrenal medulla slices. Cyclic AMP levels were not affected at the interval of the maximal increase of the catecholamine-release by acetylcholine, but increased gradually some time after the end of the release/or at the beginning of the restoration of catecholamine in the medulla tissue. This delayed increase in the medullary cyclic AMP is not attributed to a direct involvement in 'stimulus-secretion coupling process' of the medullary secretion, but rather may be caused by release of intracellular catecholamine.