Open AccessEFFECTS OF BENZODIAZEPINES AND PENTOBARBITAL ON THE EVOKED POTENTIALS IN THE CAT BRAIN
Author(s) -
Toshiro Tsuchiya,
Sumio Kitagawa
Publication year - 1976
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.26.411
Subject(s) - pentobarbital , hippocampal formation , amygdala , hypothalamus , midbrain , limbic system , neuroscience , central nervous system , hippocampus , chemistry , medicine , anesthesia , endocrinology , psychology
The sites of action of benzodiazepines, diazepam and ID-540 [7-chloro-5-(o-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one) on the central nervous system were examined and compared with those of pentobarbital using evoked potentials recorded on the limbic system and hypothalamus in the cat brain. Benzodiazepines affected the various neuronal connections of the intra-limbic, limbic-hypothalamic and midbrain-limbic systems; especially the amygdala (AMYG)-, ventromedial hypothalamus (VMH)- and central gray matter (SGC)-hippocampal (HIPP) evoked potentials were attenuated, whereas the AMYG-VMH, VMH-AMYG and the septum (SP)-VMH evoked potentials were facilitated. Pentobarbital selectively attenuated the SGC-, VMH- and AMYG-HIPP evoked potentials, or facilitated the VMH-AMYG and the SP-HIPP evoked potentials. Both benzodiazepines and pentobarbital affected three afferent hippocampal neuronal connections, areas of the reticulo-hypothalamic systems regulating hippocampal activity, while only benzodiazepines affected the neuronal influence of the amygdaloid and septal areas on the hypothalamus.