Open AccessEFFECT OF ORGANOPHOSPHORUS COMPOUNDS ON ACETYLCHOLINE SYNTHESIS IN BRAIN
Author(s) -
Makoto Muramatsu,
Kinya Kuriyama
Publication year - 1976
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.26.249
Subject(s) - acetylcholine , cholinesterase , acetylcholinesterase , chemistry , choline , parathion , isopropyl , choline acetyltransferase , paraoxon , aché , biochemistry , pharmacology , enzyme , biology , organic chemistry , pesticide , agronomy
Effects of parathion and di-isopropyl fluorophosphate (DFP) on acetylcholine (ACh) synthesis in the mouse brain were investigated. In addition to well known cholinesterase (ChE) inhibition, parathion showed inhibitory effects on the activity of synaptosomal choline acetyltransferase (ChAc), and on the uptake of [14C-methyl]-choline and ACHh synthesis in subcellular fractions of the brain. DFP inhibited ChE activity, but had no significant effects on the choline uptake and ACh synthesis per se. Possible significance of these findings in the pharmacological actions of organophosphorus compounds is briefly discussed.