EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN NORMAL AND CIRRHOTIC RATS | Zendy

Susumu Okabe | Zendy; Koji Takeuchi | Zendy; Tetsuro Urushidani | Zendy; T. Naganuma | Zendy; Keijiro Takagi | Zendy

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EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN NORMAL AND CIRRHOTIC RATS

Author(s) -

Susumu Okabe,

Koji Takeuchi,

Tetsuro Urushidani,

T. Naganuma,

Keijiro Takagi

Publication year - 1975

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.25.687

Subject(s) - carbon tetrachloride , cirrhosis , medicine , glutamine , endocrinology , ligation , chemistry , gastroenterology , biochemistry , amino acid , organic chemistry

Cirrhosis of the liver in rats was induced by the administration of carbon tetrachloride (0.1 ml/100 g of body weight, s.c.) biweekly for 13 weeks. In the pylorus ligation preparation, acetylsalicylic acid (ASA) 100 mg/kg p.o. induced much more serious gastric damage in CC14-induced cirrhotic rats as compared with rats with a normal liver. L-glutamine 750 mg/kg p.o. prevented the ASA-induced gastric lesions in both normal and cirrhotic rats, even though the degree of the inhibition was weaker in cirrhotic rats. Gastric analysis indicated that L-glutamine 750 mg/kg p.o. markedly inhibited the gastric ionic changes (acid back diffusion) in response to ASA in both cirrhotic and normal rats.

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