Open AccessEFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID-INDUCED GASTRIC LESIONS IN NORMAL AND CIRRHOTIC RATS
Author(s) -
Susumu Okabe,
Koji Takeuchi,
Tetsuro Urushidani,
Toshihiko Naganuma,
Keijiro Takagi
Publication year - 1975
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.25.687
Subject(s) - carbon tetrachloride , cirrhosis , medicine , glutamine , endocrinology , ligation , chemistry , gastroenterology , biochemistry , amino acid , organic chemistry
Cirrhosis of the liver in rats was induced by the administration of carbon tetrachloride (0.1 ml/100 g of body weight, s.c.) biweekly for 13 weeks. In the pylorus ligation preparation, acetylsalicylic acid (ASA) 100 mg/kg p.o. induced much more serious gastric damage in CC14-induced cirrhotic rats as compared with rats with a normal liver. L-glutamine 750 mg/kg p.o. prevented the ASA-induced gastric lesions in both normal and cirrhotic rats, even though the degree of the inhibition was weaker in cirrhotic rats. Gastric analysis indicated that L-glutamine 750 mg/kg p.o. markedly inhibited the gastric ionic changes (acid back diffusion) in response to ASA in both cirrhotic and normal rats.