Brain Nerve Growth Factor Unbalance Induced by Anabolic Androgenic Steroids in Rats | Zendy

Stefano Pieretti | Zendy; M. Mastriota | Zendy; Paolo Tucci | Zendy; Giuseppe Battaglia | Zendy; Luigia Trabace | Zendy; Ferdinando Nicoletti | Zendy; Sergio Scaccianoce | Zendy

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Brain Nerve Growth Factor Unbalance Induced by Anabolic Androgenic Steroids in Rats

Author(s) -

Stefano Pieretti,

M. Mastriota,

Paolo Tucci,

Giuseppe Battaglia,

Luigia Trabace,

Ferdinando Nicoletti,

Sergio Scaccianoce

Publication year - 2013

Publication title -

medicine and science in sports and exercise

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.703

H-Index - 224

eISSN - 1530-0315

pISSN - 0195-9131

DOI - 10.1249/mss.0b013e31826c60ea

Subject(s) - nerve growth factor , anabolism , anabolic androgenic steroids , endocrinology , medicine , biology , receptor

Anabolic androgenic steroids (AAS) are synthetic androgen-like compounds that are abused in sport communities despite their adverse effects. Nerve growth factor (NGF) influences neuronal differentiation and survival, and it also mediates higher brain functions such as learning and memory. Changes in NGF expression have been implicated in neurodegenerative disorders, including Alzheimer disease. Hence, we decided to study the effect of chronic AAS exposure on brain NGF profile, NGF-dependent cholinergic function, and related behavioral performance.

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