Open AccessHeterogeneity of Muscle Blood Flow and Metabolism
Author(s) -
Ilkka Hein,
Shunsaku Koga,
Kari K. Kalliokoski,
Timothy I. Musch,
David C. Poole
Publication year - 2015
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1249/jes.0000000000000044
Subject(s) - diabetes mellitus , blood flow , oxygen delivery , medicine , metabolism , cardiology , endocrinology , physiology , chemistry , oxygen , organic chemistry
The systematic increase in V˙O2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (Q˙O2)-to- V˙O2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased Q˙O2/V˙O2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance.