Open AccessMRI Reveals Brain Abnormalities in Drug-Naive Parkinson’s Disease
Author(s) -
Peggy J. Planetta,
Nikolaus R. McFarland,
Michael S. Okun,
David E. Vaillancourt
Publication year - 2014
Publication title -
exercise and sport sciences reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1249/jes.0000000000000003
Subject(s) - parkinson's disease , magnetic resonance imaging , disease , medicine , neuroimaging , functional magnetic resonance imaging , neuroscience , motor symptoms , psychology , pathology , radiology
Most brain studies of Parkinson's disease (PD) focus on patients who are already taking antiparkinsonian medication. This makes it difficult to isolate the effects of disease from those of treatment. We review magnetic resonance imaging evidence supporting the hypothesis that early-stage untreated PD patients have structural and functional abnormalities in the brain, some of which are related to motor symptoms.