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Effect of Channel Geometry on Ionic Current Signal of a Bridge Circuit Based Microfluidic Channel
Author(s) -
Hirotoshi Yasaki,
Takao Yasui,
Takeshi Yanagida,
Noritada Kaji,
Masaki Kanai,
Kazuki Nagashima,
Tomoji Kawai,
Yoshinobu Baba
Publication year - 2018
Publication title -
chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.492
H-Index - 114
eISSN - 1348-0715
pISSN - 0366-7022
DOI - 10.1246/cl.171139
Subject(s) - chemistry , channel (broadcasting) , ionic bonding , signal (programming language) , current (fluid) , microfluidics , bridge (graph theory) , geometry , nanotechnology , electrical engineering , ion , organic chemistry , programming language , engineering , medicine , materials science , mathematics , computer science
Bridge circuit based ionic current sensing in a microfluidic channel has attracted attention as a highly sensitive analytical method for bio-related molecules and particles. However, channel geometry which greatly influences the detected ionic current has not been investigated. Here, we investigate experimentally and theoretically the effect of differences in the microfluidic channel geometry on shapes and amplitude of signals in ionic current sensing. Our results clarify the geometrical effect of the channel in the bridge circuit based ionic current sensing method.

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