Silver-catalyzed Vinylic C–F Bond Activation: Synthesis of 2-Fluoroindoles from β,β-Difluoro-o-sulfonamidostyrenes | Zendy

Takeshi Fujita | Zendy; Yota Watabe | Zendy; Shigeyuki Yamashita | Zendy; Hiroyuki Tanabe | Zendy; Tomoya Nojima | Zendy; Junji Ichikawa | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Silver-catalyzed Vinylic C–F Bond Activation: Synthesis of 2-Fluoroindoles from β,β-Difluoro-o-sulfonamidostyrenes

Author(s) -

Takeshi Fujita,

Yota Watabe,

Shigeyuki Yamashita,

Hiroyuki Tanabe,

Tomoya Nojima,

Junji Ichikawa

Publication year - 2016

Publication title -

chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.492

H-Index - 114

eISSN - 1348-0715

pISSN - 0366-7022

DOI - 10.1246/cl.160427

Subject(s) - chemistry , catalysis , medicinal chemistry , stereochemistry , polymer chemistry , organic chemistry

An electrophilic 5-endo-trig cyclization of β,β-difluoro-o-sulfonamidostyrenes was performed in 1,1,1,3,3,3-hexafluoropropan-2-ol using a Ag(I) catalyst and N,O-bis(trimethylsilyl)acetamide. In this process, vinylic C–F bond activation was achieved via silver-catalyzed β-fluorine elimination, accompanied by C–N bond formation, which led to the synthesis of 2-fluoroindoles.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research