Asymmetric Synthesis of 1-Tetralones Bearing a Remote Quaternary Stereocenter through Rh-Catalyzed C–C Activation of Cyclopentanones | Zendy

Shusuke Ochi | Zendy; Ying Xia | Zendy; Guangbin Dong | Zendy

Open Access

Asymmetric Synthesis of 1-Tetralones Bearing a Remote Quaternary Stereocenter through Rh-Catalyzed C–C Activation of Cyclopentanones

Author(s) -

Shusuke Ochi,

Ying Xia,

Guangbin Dong

Publication year - 2020

Publication title -

bulletin of the chemical society of japan

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.145

H-Index - 99

eISSN - 1348-0634

pISSN - 0009-2673

DOI - 10.1246/bcsj.20200147

Subject(s) - stereocenter , tetralones , chemistry , enantioselective synthesis , catalysis , stereochemistry , organic chemistry , combinatorial chemistry

Herein, we describe the preparation of 1-tetralones bearing a remote quaternary stereocenter in a highly enantioselective manner. A sequence of Pd-catalyzed asymmetric 1,4-addition and Rh-catalyzed enantiospecific C-C/C-H activation delivers diverse 1-tetralones with a C4 quaternary stereocenter, which are prepared in good overall yields and high enantioselectivity.

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