Oscillatory Membrane Potential Changes in Cells of Mesenchymal Origin: The Role of an Intracellular Calcium Regulating System | Zendy

P. G. Nelson | Zendy; M Henkart | Zendy

Open Access

Oscillatory Membrane Potential Changes in Cells of Mesenchymal Origin: The Role of an Intracellular Calcium Regulating System

Author(s) -

P. G. Nelson,

M Henkart

Publication year - 1979

Publication title -

journal of experimental biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.367

H-Index - 185

eISSN - 1477-9145

pISSN - 0022-0949

DOI - 10.1242/jeb.81.1.49

Subject(s) - intracellular , endoplasmic reticulum , calcium , microbiology and biotechnology , biophysics , cytoplasm , mesenchymal stem cell , calcium in biology , membrane potential , chemistry , membrane , membrane permeability , biochemistry , biology , organic chemistry

A number of mesenchymal cells (fibroblasts, macrophages and megakaryocytes) respond to a variety of stimuli with large hyperpolarizations lasting several seconds (the H.A. response). The H.A. responses can occur as repetitive trains or oscillations. These hyperpolarizations are due to an increase of the surface membrane permeability to potassium ions which is probably mediated by an increase in the cytoplasmic free calcium ion concentration. Evidence is discussed which suggests that the source of this increased calcium, is least in part, an intracellular sequestering system, probably the endoplasmic reticulum. A model capable of producing oscillatory changes in membrane potential is proposed based on such an intracellular calcium sequestering and releasing system.

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