Potency of Adrenaline and Noradrenaline for β-Adrenergic Proton Extrusion From Red Cells of Rainbow Trout, Salmo Gairdneri | Zendy

Vilhelm Tetens | Zendy; Gunnar Lykkeboe | Zendy; Niels Juel Christensen | Zendy

Open Access

Potency of Adrenaline and Noradrenaline for β-Adrenergic Proton Extrusion From Red Cells of Rainbow Trout, Salmo Gairdneri

Author(s) -

Vilhelm Tetens,

Gunnar Lykkeboe,

Niels Juel Christensen

Publication year - 1988

Publication title -

journal of experimental biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.367

H-Index - 185

eISSN - 1477-9145

pISSN - 0022-0949

DOI - 10.1242/jeb.134.1.267

Subject(s) - isoprenaline , rainbow trout , agonist , potency , endocrinology , medicine , salmo , chemistry , adrenergic agonist , adrenergic , ec50 , in vivo , receptor , adrenergic receptor , trout , in vitro , fish <actinopterygii> , biology , biochemistry , fishery , stimulation , microbiology and biotechnology

The red cell adrenoceptor affinity for the unspecific agonists adrenaline and noradrenaline and the specific beta-agonist isoprenaline was studied in vitro on whole blood of rainbow trout, Salmo gairdneri at 15 degrees C. The erythrocytic adrenoceptors could be pharmacologically characterized as beta-receptors of the ‘noradrenaline’-type (beta 1-type), with an order of potency of isoprenaline greater than noradrenaline much greater than adrenaline. The adrenoceptor affinities, expressed as agonist concentrations for 50% response (EC50), were 1.3 X 10(−8) and 7.6 X 10(−7) mol l-1 for noradrenaline and adrenaline, respectively. Winter fish showed a red cell adrenergic response identical to that of summer-acclimated fish. It is concluded that most red cell beta-adrenergic responses in vivo are exclusively elicited by noradrenaline.

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