The influence of inactivity on membrane resting conductances of rat skeletal muscle fibres undergoing reinnervation | Zendy

Diana Conte Camerino | Zendy; S. H. Bryant | Zendy; Marcello Diego Lograno | Zendy; Mercede Mambrini | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The influence of inactivity on membrane resting conductances of rat skeletal muscle fibres undergoing reinnervation

Author(s) -

Diana Conte Camerino,

S. H. Bryant,

Marcello Diego Lograno,

Mercede Mambrini

Publication year - 1985

Publication title -

journal of experimental biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.367

H-Index - 185

eISSN - 1477-9145

pISSN - 0022-0949

DOI - 10.1242/jeb.115.1.99

Subject(s) - reinnervation , tetrodotoxin , anatomy , skeletal muscle , extensor digitorum longus muscle , peroneus longus , chemistry , neuromuscular transmission , biology , biophysics , endocrinology , tendon

The role of activity in the maintenance of the normal component resting conductances of skeletal muscle fibres has been evaluated in vitro in rat extensor digitorum longus muscle during reinnervation from 2 to 40 days (a) after crushing of the peroneus nerve and (b) after local application of tetrodotoxin (TTX) to the crushed nerve. Whereas membrane conductances were regained after crushing alone, they were not completely restored when impulse propagation was blocked with TTX. It is concluded that nerve trophic factors are of primary importance in the control of muscular membrane conductances, and that transmission at the endplate and the muscle usage triggered by it have a minor but significant effect.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research