Studies on the Mode of Action of Octopamine, 5-Hydroxytryptamine And Proctolin on A Myogenic Rhythm in the Locust | Zendy

Peter D. Evans | Zendy

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Studies on the Mode of Action of Octopamine, 5-Hydroxytryptamine And Proctolin on A Myogenic Rhythm in the Locust

Author(s) -

Peter D. Evans

Publication year - 1984

Publication title -

journal of experimental biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.367

H-Index - 185

eISSN - 1477-9145

pISSN - 0022-0949

DOI - 10.1242/jeb.110.1.231

Subject(s) - proctolin , locust , octopamine (neurotransmitter) , biology , rhythm , endocrinology , medicine , neuropeptide , anatomy , neuroscience , serotonin , biochemistry , ecology , receptor

The modes of action of the modulatory compounds octopamine, 5-hydroxytryptamine (5-HT) and proctolin on the frequency of the myogenic rhythm of the extensor-tibiae muscle of the hindleg of the locust, Schistocerca americana gregaria, have been investigated. 5-HT and proctolin increase the frequency of the myogenic rhythm and the results of the present study suggest that they may mediate their effects by increasing the levels of cyclic AMP in the pacemaker of the myogenic bundle. In contrast, octopamine reduces the frequency of the myogenic rhythm and appears to mediate its effects by a mechanism that does not involve an elevation of cyclic AMP. A number of other possible mechanisms for the action of octopamine are discussed.

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